今回は更年期障害の改善にNMNが有効というニュースが飛び込んできましたので、早速お伝えしたいと思います。台湾に住むリチャード夫妻がNMNを飲んでその後の改善をレポートしましたが驚くべき効果が分かりました。
この記事の結論
- NMNは奥様の更年期が逆転した。
- NMNは記憶力を強化して認知症の予防に効果が期待できる。
- トムクルーズもNMNを飲んでいて２５年前より輝いている
記事の内容
こんにちは、リチャードと申します。私と妻はデビッド・シンクレア博士のNMNの若返りアンチエイジングについて論文を読んで、とても驚きました。
そして本当にNMNに若返りの効果があるのかどうか自分たちの体で1年前からNMNの検証を行いました。
最初のころはNMNサプリメントの発送が待ちきれず３時間かけてバスに乗り買いに行ったことを覚えています。それから１年が経ちまして驚きのレポートが提出されました。
世界的に有名なマウスを使った実験を復習してみます。NMNには多くの利点があることが示されています。身体的及び精神的なパフォーマンスの向上と健康寿命の延長です。人間を対象とした試験は世界各国で現在進行中です。
現時点ではＮＭＮは人にとって安全という事は研究結果として発表されています。数年で人にとっても有益なレポートが出てくるでしょう。
生物学的年齢の若返り
さて、ここに専門機関で測定した私の生物学的年齢測定値があります。実年齢は実際の年齢で、生物学的年齢はいわいる細胞や臓器の年齢です。スタート時は差分は8.6歳です。
私は３種類のタイプのNMNをテストしました。
青は通常のサプリメントカプセル型NMNでばらつきはありますが１日150～750mgを摂取しました。すると６か月後には実年齢と生物学的年齢（細胞や臓器など体内年齢）が13.87歳も若くなりました。
このままサプリメント型を続けていたらどこまで若くなれるかトライしても良かったのですがここで舌下吸収型NMNに切り替えました。NMNの分量は増量し１日500mgから1000mg接種しましたが差分に変化はありませんでした。私の体ではここが限界だったのか舌下型では変化が見られませんでした。
次は強化吸収型という物を試しましたがこれは逆に差分が減ってしまいました。
次は私の妻のデータになります。
妻はNMNを飲み始める時に私と専門機関での試験を受けなかった為、６か月後からのデータになります。
妻はサプリメント型NMNを摂取して６か月後には実年齢と体内年齢の差が10.67歳若くなりました。
同様に舌下吸収型に切り替えた後、妻は懐疑的なのでNMNを摂取することをやめました。
すると差分が1.46歳まで縮んでしまいました。その後強化吸収型NMNを摂取したら-4.05歳まで若返りました。妻はNMNの効果にとても驚いて、嬉しそうです。これは人生でとても良い発見でNMNを飲み続けると話していました。
血液検査の若返り結果
次は私の血液検査に移りましょう。
NMNを始める前は総コレステロールとLDLコレステロールの値が高かったですが、NMNを飲んで１２か月後コレステロールが低下して範囲内になり、総コレステロールと HDL の比率が基準値に近くなりました。LDLも範囲内になりました。
リスガーデン博士には、データを見ると男性の死亡率が最も高いLDLレベルが140なので注意しなさいと言われました。
私はこの現在の値に満足しており、私のトリグリセリドは年間で上昇しているので、下げたいと考えています。私はトリグリセリドを下げることはほとんど試しています。食物繊維とオメガ3の摂取量も増やしました。
これが妻の血液検査です。
妻はNMNを摂取して１年後にはLDLコレステロールとトリグリセリドは下がり、トリグリセリド HDL 比は改善されました。これらの数値はすべてオールグリーンとなりました。
肝臓検査の若返り結果
次に私の肝臓検査番号があります。
１年後尿酸値が範囲を超えましたが、NMN検証の為にセロリシード抽出物を辞めたのが原因のようです。そして私は１年後AST/ALTが適正値になりました。
これは妻の肝臓検査の結果です。
妻の尿酸値も高いですが、理由は私と同じです。
妻はASTとASTtoALTの比率が現在の範囲内に改善されていることを確認しました。
肝臓についても、尿酸に注意する必要があることを除けば、問題ないようです。
身体測定の若返り結果
これは、1年間の身体測定の要約です
私はNMNで体重が減り、特に体脂肪率がかなり改善されたのでとても満足しています。
私の妻はもともと痩せているので体重の変化はあまりありませんでした。
これが血圧と安静時心拍数の結果です。
私も妻も血圧が少し改善されて嬉しいです。
これらのグラフは安静時心拍数の平均を示しています
あなたは私のものが期間にわたって少し改善したことがわかります。
認知症・記憶力の若返り結果
私と妻は作業記憶をテストするゲームも行っていました。これは点数の推移です。
NMNを摂取する前は私はレベル２、妻はレベル６でしたがNMNを飲んで１年後には私はレベル７妻はレベル１３まで伸ばすことができました。NMNは認知症を防ぐ可能性を示しています。NMNを辞めると彼女の点数はレベル９まで下落しました。
肌としわの若返り結果
これが私たちの肌のレポートです。2019年はかなり老けて見えますがEARLY2020がNMN飲み始めで、LATE2020がNMNを飲んで１年後です。肌質が確実に改善されてしわがなく艶があります。
トムクルーズもNMNを飲んでいることで有名です。彼は２５年前とほとんど変わらないように見えます。
そして最後に彼女は更年期が逆転したことを喜んでいます。
更年期障害は、私にとってより長い寿命を示している可能性が高いようです
まとめ
リチャード氏の奥様はNMNは女性の更年期障害を巻き戻すと話しています。また生物学的年齢を１３歳以上若返らせ認知症の改善にも効果があります。体が若返えるのは全ての病気や障害に万能なサプリメントと言えますね。
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本文
hello everyone this is richard from modern healthspan as i’m not recording this video at home please forgive the background
after viewing the videos and reading the papers by dr david sinclair
we started our NMN and resveratrol trial one year ago i still remember after listening to all
the talks by dr sinclair
we were very excited about NMN
and just could not wait for shipping and decided to take a three-hour return bus journey to get our first bottle of NMN in hong kong
this cost 780 hong kong dollars which is about 100 us doll
so time flies
now it is one hour one year anniversary
and this is our first year report first a disclaimer we are just sharing our experience and the protocols that
we’re using in our anti-aging journey
this video does not provide any medical advice
we have very briefly why are we taking NMN in mouse models
NMN has been shown to have a number of benefits
including improving physical and mental performance and extending health span
there are trials currently on going for humans
but at the moment
the only completed trial is on safety
we are following the progress of these trials
and provide updates when we hear anything
we are hoping that
these benefits will translate into humans
let’s see how we are going after one year
there have been a couple of studies
a couple of studies have shown age reversal in humans
the first of these use growth hormone with metformin and dhea
and the second of which used only diet and lifestyle
though neither used NMN
it does show that age can be reversed
but when we say age what do we mean we are referring to the biological age
not the chronological age
in this case
we are using epigenetic clocks to measure what a person’s biological age is we use epi age which has a service that only requires a saliva sample
and there is a link with a 10 discount in the description
here are my biological age measurements
when compared to my chronological age
the top line is my chronological age and the second line is my biological age
these are
both shown on the left hand axis
the lower line is the difference between them shown on the right hand axis as
this line shows the difference between my chronological age and the biological age
lower numbers are better
here are the various NMN doses and formats that i have been taking in the blue area
i was using powder and capsules with a starting dose of 150 milligrams up to 750 milligrams
i then used sublingual NMN at one gram for three month trial
we did have some lozenges left over
so that period actually extended beyond the three months
i’m now in the yellow area with enhanced absorption at 900 milligrams
you can see i started off at 50 which was eight years younger than my chronological age
around when i started taking NMN and in the last test
i was 46.23 at 13 years younger than my chronological age
before we jump into my wife’s age data
let’s take a look at another possible effect of NMN in mouse models
it has been shown that NMN can reverse age-induced infertility
there are two major studies on this topic both published in cell last year
this one was published in february entitled nad plus repletion rescues female fertility during reproductive aging
the researchers included dr lindsey wu and dr david sinclair
they showed that mice who had aged beyond their fertile period
when provided with low doses of NMN had notably better egg quality and were able to give birth to offspring
during a breeding trial
another paper was published in august entitled nicotinamide mononucleotide supplementation reverses the declining quality of maternal aged oocytes
it states that NMN supplementation improved the quality of the maternal aged eggs and provides a potential strategy to improve reproductive outcomes of women of advanced maternal age
according to United Kingdom National Health Service
for most women the menopause starts between the ages of 45 and 55.
my wife’s period stopped last year before she took any NMN
it also stopped for many of her friends who were the same age so she thought it was normal
it was unexpected
but after taking NMN her period came back not just this it came back in a youthful way
she has been through the usual perry many poor stage symptoms
and then
her period stopped according to her
she feels like
her period now is the same as when she was in her twenties less menstrual cramp and period fatigue
we did not want to mention it in our earlier report as we wanted to wait longer to see if it really continues or it only came back for one or two months interestingly
it is continuing a final note on this after her periods are back to normal
for a while NMN seems to have the effect of prolonging them
so now her policy is to stop taking NMN when the period comes and then retake it when it has finished
and so far this policy has been working well for her as i mentioned in several videos
before my wife has a skin allergy which she had before taking NMN in these last few years
she has had rashes on her hands which come and go she hoped NMN may help
but it seems not during curving 19 her allergy has got worse
she is especially sensitive to the antiseptic spray which many families use to spray their hands and shoes when they go into their flats
she gets headaches dizziness and skin itchiness
even when she just smells the spray from our neighbors
it is serious enough that she needs to sit down and cannot stand on top of that we found that her skin rashes are getting worse red and swollen after she has eaten certain kinds of food as well
it seems that there are countless factors that contribute to her allergy so she decided to start an elimination diet
and also stop taking all supplements except vitamins b c and d
and then to add them back one at a time
let’s see how she is doing in her biological age with all her inflammation
and not taking NMN here we will talk about the difference between my wife’s chronological age and her biological age
you can see on her first test
she was 10.67 years younger but in her next test
she dropped to only 1.46 years younger
and then in the most recent test she was back to 4.05 years younger
you can also see the NMN format
and dose that she was taking note that my wife did not take the first age test with me
that is why the graph starts at six months and she was taking NMN before the first test that she did between the six and the nine months
we are not sure whether her allergies accelerated her aging or not taking NMN may have also contributed
she restarted taking NMN a month before the last age test her allergic status was not much changed although
there seems no adverse effects after retaking NMN
and overall
her biological age is still younger than her chronological age by four years
so she is feeling a bit better in the lab tests that we do
they also estimate your metabolic age
you can see here that for me the metabolic age is in quite close agreement with my epi age
now let’s move on to some of the key blood markers my overall
cholesterol has come down to be in range and my total cholesterol to hdl ratio is now close to optimal my ldl is out of range
but in our recent talk with dr Lisgarden and the video on his site
he pointed out that the data shows an ldl level of 140 being optimal for all-cause mortality in NMN
i am therefore happy with this current value my triglycerides have gone up over the year so i would like to control them
i’m doing most of the things that should benefit triglycerides
but i’ve also increased my fibre and omega-3 intake
and here is my wife’s numbers
her ldl is good and has gone up during the period while her ldl has gone down
optimal ldl levels are different for women and again
following dr luskan’s research about 100 is optimal
her triglycerides have come down and her triglycerides hdl ratio has improved
so after one year of taking NMN all these numbers are looking okay
for both of us and here are my liver test numbers
uric acid is back above range
this may be because of NMN
as b3 or niacin can be a cause of elevated uric acid apart from drinking some alcohol
i do not do the other things that would generally raise uric acid the dip
and rise of uric acid is also coincides with our stopping and then restarting celery seed extract
we have recently restarted with this
and are now having more fiber in our diet
and will aim to drink more water
and see how this number is at the next checkup ast
and alt are key enzymes in the liver and high levels of them in the blood
may be a sign of liver damage as one of the concerns with NMN is that it may deplete methyl groups and cause issues in the liver there are numbers which we are closely watching overall my ast and alt ratio has improved where it is now below 1.
here are my wise numbers
her uric acid is also high though less than it was the comments on my uric acid levels also apply to her
she has seen improvements in her ast and ast to alt ratio to where these are now in range
so for liver we also seem to be okay except that we need to keep an eye on the uric acid
here is a summary of our physical measurements over the year
i have lost some weight and i’m now happy where i am just need to put on some muscle
my wife has not lost much weight but then she is underweight so that is a good thing
we did change our scales in the middle of the year
which means that the muscle mass and bone mass numbers are not directly comparable
here is the result of the blood pressure and resting heart rate
i’m glad to see a little progress on the blood pressure
these charts show our average resting heart rate
you can see that mine has improved a little over the period
here is a tweet from dr sinclair showing that
he too watches his resting heart rate as one of the key metrics here he has reached a level of 49 beats per minute
we use garmin watches to check our resting heart rate
i take NMN after finishing my meditation in the morning
here is a picture of my wife and my watches with some of our best values
we track our sleep using a free app which is available for ios and android
my numbers are quite variable and generally not that good
for november my average was 72 percent
i do not at the moment know why this is
and it’s something i need to investigate my wife generally does better her average for november was 90
here are a couple of screenshots for our best results where my wife got a perfect 100 on the excise front
it has been a difficult year for aerobic we’ve been doing some running
but i am down from where i was in 2019
when i was at a vo2 max of 52.
this was the best i have ever been since i started tracking
and it was just after i started taking NMN as you can see now i am at 45 and trying to increase this
my wife was at 47 when she last ran back in october according to the garmin database
her vo2 max is in the top 1 for her age and gender group
if any of you watched the recent video on our dna testing
you will recall that her genes favor her cardio ability and this result does seem to support that for strength training
i was planning to do a one rep max measure
but after the interview with professor keith barr
i will instead use his plan for this
i will pick five exercises and for each of them choose a weight where i cannot quite complete 12 slow reps
when i can complete 12 reps i will move up to the next weight and keep track of my progress
here is my list of exercises
but at the moment the gyms are closed
so i will start as soon as they reopen and this is the seven minute exercises which we introduced in the nine month report
my wife continues to do these most mornings
no major changes to our eating habits
low carbs no sugars no highly processed foods
we continue with a restricted eating window
as i mentioned earlier my wife started an elimination diet
she finally took a food intolerance test last month
and has just received her report
here is part of
it the items in red show the foods that she has sensitivities to
and the number designating the level of that sensitivity
she seems to be sensitive to quite a lot with this information
she can now really start her elimination diet without just guessing
we covered NMN earlier on the biological age slide
here are the other supplements that we have taken we have not taken all of them all the time and the dose has varied
but this is the core set of supplements as we mentioned
my wife has gone on an elimination diet and there are periods when she has not been taking supplements on top of these
we also take various probiotics and protein and collagen after exercise after listening to dr Leusgarten
i have reintroduced acacia soluble fiber and also dried parsley
and celery seed extract as sources of epigenet which inhibits cd38 a big user of nad
we have links to all of the supplements in the description
we mentioned duel and back in our earlier video about free apps to track
and improve our mental well-being if you want to find out more
please find the link above on the screen duel and back is a science-based game
which has been shown to improve working memory you need to remember both location plus
the sound of a square each time my wife and i started just after taking NMN to measure our cognitive progress
my wife has made great progress here the app has a screen which tracks your progress over time
when you start the game the top level is 12.
as she made it to level 13 now her screen shows up to 15 levels in the last four months
she is typically played for about two minutes a day
it’s interesting that when she’s taking NMN she can normally maintain her level
however when she stops the NMN she drops the game level all the time
so this is our hair report
you can see that my wife has improved her hair poor status
my wife has said that i seem to have more hair and the top of my hair has got darker
and i have found that my wife’s hair seems to be more lustrous
here is a section from the report where they are examining the health of the cuticle
and you can see that i’ve gone from three to four stars for skin and wrinkles
i don’t have much change but my wife said my skin does look tighter especially in the neck area
she also says that i sound younger when i’m talking dr david sinclair took NMN for three years
he seems to have a lot less wrinkles now
i have only taken NMN for one year
dr sinclair also tweeted out his previous passport photo from a decade ago and the recent update
he does even look younger when compared to 10 years ago after 10 years
i will be 70 so there is hope that at the time i will look even younger than now
by the way he also tweeted out tom cruise photo from 25 years ago
and now he is also looking really young for my wife
she is amazed at the positive progress that she has made in both physical and mental functions within a year in the NMN trial of course
she is happy that her menopause has been reversed as menopause age seems related to longevity later
menopause seems likely to indicate a longer lifespan for me
the journey has been very enriching
i’ve learned a lot of things and see so much possibility for the future
i feel really good and think that my physical fitness would be better
if it was not for covid 19 making it difficult to get outside and to go to the gym
we look forward to next year and plan to keep up the regular reports and add more ways of measuring our health
we would like to thank you all for following along with us
and do hope that the information we provide is helpful to you
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